Utica College Asa Gray Series Presents: Graduate School, Basic Immunology and Antibody Deficiencies

By Cindy McNicholl

Event Details

Date(s) & Time(s)::

March 24, 2014 at 4:00 PM

Location: Donahue Auditorium at Utica College


Event Description

Ewa Szymanska Mroczek, Ph.D., University of Alabama at Birmingham, will discuss depressed serum immunoglobulin levels (sIgs) and recurrent sinopulmonary infections that mark Common Variable Immune Deficiency (CVID). Many family members of CVID patients also suffer recurrent sinopulmonary infection (RESPI) but have normal sIg. She identified HLAB44 positive identical female twins who suffer sinopulmonary infections and are discordant for CVID and RESPI. Her findings suggest that in addition to an acquired block in B cell development at the transitional stage, the CVID twin produces an immunoglobulin (Ig) repertoire that is markedly depleted of tyrosine. This may explain why the function of the Ig repertoire in CVID is more impaired than what might be expected by sIgs levels.
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