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Pfizer and BioNTech begin large-scale trial of coronavirus vaccine in the United States

Drug giant Pfizer and its partner BioNTech have begun an advanced trial of one of their experimental coronavirus vaccines in volunteers in the United States....

Posted: Jul 29, 2020 4:17 PM
Updated: Jul 29, 2020 4:17 PM

Drug giant Pfizer and its partner BioNTech have begun an advanced trial of one of their experimental coronavirus vaccines in volunteers in the United States.

The first four participants were dosed Monday at the University of Rochester Medical Center, a spokesman there said. The combined Phase 2/3 trial, which looks for safety, efficacy and optimal dosing of a vaccine or drug, will include up to 30,000 participants.

It was the second advanced trial of a coronavirus vaccine to get under way in the United States Monday. Earlier Monday, Moderna started a Phase 3 trial in the United States of its experimental vaccine. Pfizer's vaccine is different, but also uses an experimental approach that employs genetic material to stimulate an immune response against a key part of the coronavirus.

Earlier this month, Pfizer and BioNTech released preliminary data showing that one of their vaccines, known only by its experimental name BNT162b1, appeared safe and elicited antibody and T-cell immune responses in a Phase 1/2 trial.

But the company has moved ahead with a slightly different candidate. This one will move forward in the combined Phase 2/3 trial, at about 120 sites worldwide, including 39 US states and Argentina, Brazil and Germany.

Pfizer's coronavirus vaccines all use pieces of genetic material to prompt the vaccine recipient to make antibodies against specific parts of the coronavirus. Pfizer and BioNTech's first vaccine targeted a piece of the spike protein, a structure the virus uses to infect human cells. The second vaccine, being moved into advanced trials, targets the entire spike structure.

"This decision reflects our primary goal to bring a well-tolerated, highly effective vaccine to the market as quickly as possible, while we will continue to evaluate our other vaccine candidates as part of a differentiated COVID-19 vaccine portfolio," BioNTech founder Dr. Ugur Sahin said in a statement.

Moncef Slaoui, chief adviser to the US government's Covid-19 vaccine effort, Operation Warp Speed, said building on earlier, tested vaccine platforms allows speedier development of vaccines while still being safe. "We're selecting very carefully and thoughtfully vaccine technologies that are very likely to work, and work for us, because we know them somewhat," Slaoui said Tuesday at the privately sponsored Disease Prevention and Control Summit.

Both versions of Pfizer's vaccine elicit antibody responses as well as immune cells called T-cells, the company said. If a vaccine activates both arms of the immune system the hope is it will be more effective and provide more durable protection.

A Phase 1 study typically involves a small number of people and focuses on whether a vaccine is safe and elicits some kind of immune response. In Phase 2, the clinical study is expanded and the vaccine is given to people who have characteristics -- such as age and physical health -- similar to those for whom the new vaccine is intended, according to the US Centers for Disease Control and Prevention. In Phase 3, the vaccine is given to thousands of people and tested for efficacy and again for safety.

If the vaccine works, Pfizer and BioNTech say they're on track to seek regulatory review as early as October, and if it wins emergency authorization from the US Food and Drug Administration, they could supply up to 100 million doses by the end of 2020, and about 1.3 billion by the end of 2021.

Last week the US Department of Health and Human Services and Department of Defense announced a $1.95 billion agreement with Pfizer to produce 100 million doses of a Covid-19 vaccine. The deal also allows the US government to acquire an additional 500 million doses.

Pfizer and BioNTech's vaccine is one of 25 in clinical trials around the world, according to the World Health Organization.

According to Johns Hopkins University's tally of cases in the United States, more than 4.2 million cases of coronavirus have been confirmed in the United States and more than 148,000 people have died.

New York Coronavirus Cases

County data is updated nightly.

Cases: 1611031

Reported Deaths: 47156
CountyCasesDeaths
Queens2061178675
Kings2046548996
Suffolk1595713049
Nassau1452902890
Bronx1402445807
Westchester1055502078
New York1005843852
Erie640661585
Richmond558791558
Monroe51913977
Rockland37948884
Orange36102720
Onondaga32054620
Dutchess21862404
Albany20526328
Oneida19519475
Niagara15100309
Broome14412333
Saratoga11723145
Schenectady10685177
Ulster9854226
Rensselaer8860130
Putnam820486
Chautauqua7213122
Chemung6397130
Oswego593589
Ontario569988
Steuben5452137
St. Lawrence533680
Cayuga531287
Jefferson468163
Sullivan466259
Herkimer4531106
Wayne440964
Genesee4335118
Cattaraugus432476
Madison379284
Livingston347855
Clinton346826
Tompkins341442
Columbia334794
Fulton324580
Montgomery3121105
Cortland310260
Allegany285681
Warren279555
Wyoming277848
Tioga277156
Greene259869
Orleans242280
Chenango239069
Washington227952
Otsego226743
Lewis202630
Franklin199612
Seneca156453
Delaware146933
Essex131726
Schoharie117612
Yates101126
Schuyler85212
Hamilton2772
Unassigned217137
Out of NY0191
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